Published: 23.07.2018 10:32

Hepatoprotective activity of nyctanthes arbortristis

«Hepatoprotective activity of nyctanthes arbortristis» in pictures.

Literature review on nyctanthes arbor tristis

The authors are thankful to the Chancellor, VIT-University, Vellore and Dean, School of Biotechnology, Chemical and Biomedical Engineering for providing the necessary facilities and support.

Hepatoprotective and antipyretic effect of bark of nyctanthes arbortristis

The test organisms were Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The zone of inhibition and Minimum Inhibitory Concentration (MIC) of the extracts were ascertained and compared with the standard drugs ciprofloxacin and fluconazole. The chloroform extract was found to have both antibacterial and antifungal activity whereas the petroleum ether and ethanol extracts possess only antibacterial activity 8.

Hepatoprotective Activity of Stem Bark of Nyctanthes arbor-tristis linn

Research Journal of Pharmacology and Pharmacodynamics
Year : 7565, Volume : 7, Issue : 8
First page : ( 679) Last page : ( 678)
Print ISSN : 5975-9957. Online ISSN : 7876-5886.
Article DOI : /7876-

Description of plant: NAT is a large shrub with flaky grey bark 65 and height up to 65 m tall  , stiff whitish hair, branches 66 and rough leaves 8. It has fragrant flowers with five to eight lobes which are white in colour, and corolla is orange coloured centrically they are produced in clusters of two to seven together, with individual flowers opening at dusk and finishing at dawn 65.

The bright orange corolla tubes of the flowers contain a colouring substance nyctanthin, which is identical with α-Crocetin (C 75 H 79 O 9 ) from Saffron. The corolla tubes were formerly used for dyeing silk, sometimes together with Safflower or turmeric 7. The rural people of Chittoor district Andhra Pradesh (India) widely use the whole plant for treatment of cancer, root for pyrexia, sciatica, anorexia bark as expectorant 69.

The study details were explained to patients in their language as to the drug information, study procedure, the degree of inconvenience due to frequent venipunctures, temperature recording and modes of assessment for clinical response and safety. Patients were enrolled, only if they agreed to participate in the study, after taking their written informed consent and were admitted to the Kaya-chikitsa (Internal Medicine) ward. In case of patients below 68 years old (n = 7), consent was given by the parents.

Chemical constituents: In previous studies, it was reported the isolation of polysaccharides, iridoid glycosides, henylpropanoid glycoside, ß-sitosterol, ß-amyrin, hentri-acontane, benzoic acid, glycosides, nyctanthoside-a iridoid, nyctanthic acid, Friedelin and lupeol and oleanolic acid and 6-ß-hydroxylonganin and iridoid glucosidesarborsides A, B and C, alkaloids, Phlobatanins, terpenoids and cardiac glycosides. Iridoid glucosides (arbortristosides- A, B, C) and 6-ß-hydroxyloganin has also been isolated from this plant 75.

Potential herbal-drug interaction: NAT has been reported with variety of pharmacological actions such as antispasmodic activity which indicated that inhibition of contractile response of acetylcholine 79 might potentiate the action of certain drug like Dicyclomine, Atropine, Hyoscine, Propantheline, Oxyphenonium etc.

Ten out of 75 patients showed both fever and parasite clearance, which was confirmed by polymerase chain reaction. Remaining ten patients had persistent but decreasing parasitemia. Four of them needed chloroquine as a fail-safe procedure. Irrespective of the degree of parasitemia all the patients showed decrease in MS. There was also an increase in platelet count and normalization of plasma lactic acid. There was a good clinical tolerability and an improvement in organ function. The inflammatory cytokines showed a reduction particularly in TNF-α within a day.

The clinical tolerability of the paste of N. arbor-tristis was assessed by a careful daily monitoring of the adverse events and physical examination. Adverse events were evaluated and the causality was ascribed as per the criteria of Karch and Lasagna [67]. Any new symptom, sign or a marked change in organ function test, after intervention and not expected to a natural history of malaria was considered as adverse drug event (ADE). ADEs were recorded as to their onset, severity and duration. Measures taken for the assessment and treatment of ADE were recorded. Laboratory investigations (day 5, 6st, 8rd, 7th) viz. complete blood count and markers of liver and kidney functions for the organ safety were carried out.